in NFL history

Couldn't find a definite answer. However. it is pretty rare to see anything above 14 points. I believe New England is something like a 16.5 favorite against Buffalo this week. That is a larger margin than any game from last season.

There's probably been a game in the low 20's at some point within the last few years, but those are few and far between.

When? This year or previous years.

I don't know, but that 16-17 points NE is laying against Buffalo has to be up there. I think I remember the 49ers were laying about 20 against the Chargers in a Super Bowl back in the early or mid 1990s. I think that was the highest I had ever seen in an NFL game.